| 4. Round | 28/08/2010 | Huracán | - | Newell's Old Boys | 1:1 | ||||
| 5. Round | 05/09/2010 | Newell's Old Boys | - | Independiente | 1:1 | ||||
| 6. Round | 12/09/2010 | Argentinos Juniors | - | Newell's Old Boys | 1:2 | ||||
| 7. Round | 19/09/2010 | Newell's Old Boys | - | River Plate | 1:0 | ||||
| 9. Round | 02/10/2010 | Newell's Old Boys | - | Vélez Sarsfield | 2:0 | ||||
| 10. Round | 10/10/2010 | Newell's Old Boys | - | Quilmes | 1:1 | ||||
| 11. Round | 17/10/2010 | Banfield | - | Newell's Old Boys | 0:0 | ||||
| 13. Round | 06/11/2010 | Godoy Cruz | - | Newell's Old Boys | 0:0 | ||||
| 14. Round | 15/11/2010 | Newell's Old Boys | - | Racing Club | 0:2 | ||||
| 16. Round | 28/11/2010 | Newell's Old Boys | - | Boca Juniors | 1:0 |  |
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| 17. Round | 05/12/2010 | San Lorenzo | - | Newell's Old Boys | 0:0 | ||||
| 18. Round | 09/12/2010 | Newell's Old Boys | - | Olimpo de Bahía Blanca | 0:1 | ||||
| 19. Round | 12/12/2010 | Colón de Santa Fe | - | Newell's Old Boys | 1:0 |
Argentina