| 1. Round | 28/07/2021 | Venados FC | - | Club Celaya | 1:2 | ||||
| 2. Round | 03/08/2021 | Club Celaya | - | TM Fútbol Club | 0:0 | ||||
| 3. Round | 10/08/2021 | Atlético Morelia | - | Club Celaya | 2:1 | ||||
| 4. Round | 18/08/2021 | Club Celaya | - | Coyotes de Tlaxcala | 3:0 |  |
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| 6. Round | 02/09/2021 | Club Celaya | - | Pumas Tabasco | 1:2 | ||||
| 7. Round | 09/09/2021 | Tepatitlán | - | Club Celaya | 0:1 | ||||
| 8. Round | 19/09/2021 | Atlante | - | Club Celaya | 1:1 | |
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| 10. Round | 29/09/2021 | Correcaminos UAT | - | Club Celaya | 1:0 | ||||
| 11. Round | 06/10/2021 | Club Celaya | - | Cimarrones de Sonora | 1:0 | ||||
| 12. Round | 14/10/2021 | Leones Negros | - | Club Celaya | 1:2 | ||||
| 13. Round | 20/10/2021 | Club Celaya | - | Alebrijes de Oaxaca | 1:0 | |
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| 14. Round | 27/10/2021 | Mineros de Zacatecas | - | Club Celaya | 3:1 | ||||
| 15. Round | 03/11/2021 | Club Celaya | - | Dorados de Sinaloa | 2:2 | ||||
| 16. Round | 12/11/2021 | Tapatío | - | Club Celaya | 1:1 | |
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| 17. Round | 17/11/2021 | Club Celaya | - | Cancún FC | 3:1 | |
Mexico