| 2. Round | 22/08/2021 | FC Twente | - | AFC Ajax | 1:1 | ||||
| 5. Round | 18/09/2021 | AFC Ajax | - | SC Cambuur | 9:0 |  |
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| 6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
| 8. Round | 03/10/2021 | AFC Ajax | - | FC Utrecht | 0:1 | ||||
| 12. Round | 07/11/2021 | AFC Ajax | - | Go Ahead Eagles | 0:0 | ||||
| 14. Round | 28/11/2021 | Sparta Rotterdam | - | AFC Ajax | 0:1 | ||||
| 15. Round | 02/12/2021 | AFC Ajax | - | Willem II | 5:0 | |
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| 16. Round | 12/12/2021 | AFC Ajax | - | AZ Alkmaar | 1:2 | ||||
| 20. Round | 23/01/2022 | PSV Eindhoven | - | AFC Ajax | 1:2 | ||||
| 21. Round | 06/02/2022 | AFC Ajax | - | Heracles Almelo | 3:0 | ||||
| 22. Round | 13/02/2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
| 23. Round | 19/02/2022 | Willem II | - | AFC Ajax | 0:1 | ||||
| 24. Round | 27/02/2022 | Go Ahead Eagles | - | AFC Ajax | 2:1 |
Brazil
