| 2. Round | 03/08/2000 | Huracán | - | Rosario Central | 3:1 | ||||
| 4. Round | 26/08/2000 | River Plate | - | Rosario Central | 4:1 |  |
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| 5. Round | 05/09/2000 | Rosario Central | - | Vélez Sarsfield | 2:2 | |
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| 8. Round | 22/09/2000 | Rosario Central | - | Independiente | 1:1 | ||||
| 9. Round | 30/09/2000 | Talleres de Córdoba | - | Rosario Central | 2:0 | ||||
| 10. Round | 14/10/2000 | Rosario Central | - | CA Los Andes | 6:2 | ||||
| 11. Round | 21/10/2000 | San Lorenzo | - | Rosario Central | 4:1 |  |
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| 14. Round | 10/11/2000 | Rosario Central | - | Argentinos Juniors | 1:0 | |
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| 15. Round | 18/11/2000 | Unión de Santa Fe | - | Rosario Central | 3:0 | ||||
| 19. Round | 15/12/2000 | Belgrano de Córdoba | - | Rosario Central | 1:4 |
Argentina