| 4. Round | 05/02/2022 | CF América [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 5. Round | 12/02/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 6. Round | 19/02/2022 | UANL Tigres [U20] | - | Atlético San Luis [U20] | 1:1 | ||||
| 7. Round | 26/02/2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 8. Round | 02/03/2022 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 2:3 | ||||
| 9. Round | 06/04/2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 |  |
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| 13. Round | 09/04/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:1 |  |
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| 14. Round | 15/04/2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 15. Round | 20/04/2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | |
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| 16. Round | 24/04/2022 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 17. Round | 01/05/2022 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 2:2 | |
Mexico
USA