| 9. Round | 30/08/2021 | Unión de Santa Fe II | - | Argentinos Juniors II | 1:2 |  |
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| 10. Round | 03/09/2021 | Estudiantes II | - | Argentinos Juniors II | 2:0 | ||||
| 11. Round | 10/09/2021 | Argentinos Juniors II | - | Patronato de Paraná II | 3:0 | |
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| 12. Round | 16/09/2021 | Platense II | - | Argentinos Juniors II | 2:2 | |
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| 13. Round | 27/09/2021 | Argentinos Juniors II | - | Racing Club II | 2:1 | |
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| 14. Round | 01/10/2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán II | - | Argentinos Juniors II | 0:0 | ||||
| 17. Round | 21/10/2021 | Argentinos Juniors II | - | Colón de Santa Fe II | 2:1 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | |
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| 19. Round | 01/11/2021 | Argentinos Juniors II | - | Lanús II | 2:1 | ||||
| 20. Round | 09/11/2021 | Huracán II | - | Argentinos Juniors II | 1:0 |
Argentina