| 1. Round | 28/08/2021 | Alphense Boys [U21] | - | Roda JC Kerkrade [U21] | 3:1 |  |
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| 2. Round | 11/09/2021 | Vitesse [U21] | - | Alphense Boys [U21] | 1:2 | ||||
| 3. Round | 18/09/2021 | Alphense Boys [U21] | - | SBV Excelsior [U21] | 1:0 | ||||
| 4. Round | 25/09/2021 | Willem II [U21] | - | Alphense Boys [U21] | 5:2 | ||||
| 6. Round | 16/10/2021 | Alphense Boys [U21] | - | FC Emmen [U21] | 0:0 | ||||
| 12. Round | 05/02/2022 | Roda JC Kerkrade [U21] | - | Alphense Boys [U21] | 2:2 | ||||
| 13. Round | 12/02/2022 | Alphense Boys [U21] | - | De Graafschap [U21] | 1:3 |
Netherlands
Suriname