| 1. Round | 14/08/2021 | İstanbulspor AŞ | - | Manisa FK | 3:4 |  |
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| 2. Round | 22/08/2021 | Manisa FK | - | Denizlispor | 1:0 | ||||
| 3. Round | 29/08/2021 | Gençlerbirliği | - | Manisa FK | 0:3 | ||||
| 4. Round | 11/09/2021 | Manisa FK | - | BB Erzurumspor | 0:1 | ||||
| 5. Round | 15/09/2021 | Menemen Belediyespor | - | Manisa FK | 2:0 | ||||
| 9. Round | 17/10/2021 | Manisa FK | - | Adanaspor | 0:3 |  |
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| 10. Round | 22/10/2021 | MKE Ankaragücü | - | Manisa FK | 2:1 | |
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| 11. Round | 30/10/2021 | Manisa FK | - | Boluspor | 2:2 | ||||
| 12. Round | 06/11/2021 | Samsunspor | - | Manisa FK | 1:0 |  |
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| 20. Round | 09/01/2022 | Manisa FK | - | İstanbulspor AŞ | 1:2 |
Jamaica