| 3. Round | 02/03/2022 | Unión San Felipe | - | Rangers | 1:0 |  |
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| 4. Round | 08/03/2022 | Santiago Morning | - | Unión San Felipe | 1:1 | ||||
| 6. Round | 23/03/2022 | Unión San Felipe | - | Deportes Melipilla | 1:0 | |
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| 7. Round | 04/04/2022 | Barnechea | - | Unión San Felipe | 0:1 | ||||
| 8. Round | 12/04/2022 | Unión San Felipe | - | San Luis | 2:0 | ||||
| 9. Round | 16/04/2022 | Universidad de Concepción | - | Unión San Felipe | 1:3 |  |
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| 10. Round | 22/04/2022 | Unión San Felipe | - | Deportes Temuco | 0:0 | |
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| 12. Round | 29/04/2022 | Unión San Felipe | - | Cobreloa | 1:1 | ||||
| 13. Round | 08/05/2022 | CD Magallanes | - | Unión San Felipe | 1:0 | ||||
| 14. Round | 12/05/2022 | Unión San Felipe | - | Santa Cruz | 2:1 | |
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| 16. Round | 21/05/2022 | Unión San Felipe | - | Deportes Iquique | 2:0 | ||||
| 2. Round | 26/05/2022 | Deportes Copiapó | - | Unión San Felipe | 0:1 | ||||
| 17. Round | 31/05/2022 | Fernández Vial | - | Unión San Felipe | 1:1 | ||||
| 1. Round | 06/06/2022 | Unión San Felipe | - | Recoleta | 0:0 |
Argentina