| 1. Round | 14/02/2021 | San Lorenzo | - | Arsenal de Sarandí | 2:1 | ||||
| 2. Round | 23/02/2021 | Colón de Santa Fe | - | San Lorenzo | 2:0 | ||||
| 3. Round | 28/02/2021 | San Lorenzo | - | Central Córdoba SdE | 0:4 |  |
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| 4. Round | 07/03/2021 | San Lorenzo | - | Huracán | 1:1 | |
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| 5. Round | 15/03/2021 | Banfield | - | San Lorenzo | 0:0 | ||||
| 6. Round | 21/03/2021 | San Lorenzo | - | Aldosivi | 1:2 | ||||
| 7. Round | 29/03/2021 | Estudiantes | - | San Lorenzo | 0:2 | ||||
| 8. Round | 02/04/2021 | San Lorenzo | - | Rosario Central | 2:0 | ||||
| 10. Round | 17/04/2021 | San Lorenzo | - | Argentinos Juniors | 1:1 | ||||
| 11. Round | 25/04/2021 | River Plate | - | San Lorenzo | 1:2 | ||||
| 12. Round | 02/05/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 13. Round | 09/05/2021 | Racing Club | - | San Lorenzo | 2:0 | |
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