| 1. Round | 06/01/2019 | Deportivo Guadalajara | - | Club Tijuana | 2:0 | ||||
| 2. Round | 13/01/2019 | Club Tijuana | - | UANL Tigres | 0:3 | ||||
| 3. Round | 21/01/2019 | Club León | - | Club Tijuana | 0:1 | ||||
| 4. Round | 26/01/2019 | Cruz Azul | - | Club Tijuana | 1:0 |  |
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| 5. Round | 03/02/2019 | Club Tijuana | - | Deportivo Toluca | 2:0 | ||||
| 6. Round | 11/02/2019 | Santos Laguna | - | Club Tijuana | 1:1 | ||||
| 7. Round | 16/02/2019 | Club Tijuana | - | CD Veracruz | 3:0 | ||||
| 8. Round | 24/02/2019 | Club Necaxa | - | Club Tijuana | 1:2 | ||||
| 9. Round | 02/03/2019 | Club Tijuana | - | Atlas Guadalajara | 3:1 | ||||
| 10. Round | 09/03/2019 | CF Pachuca | - | Club Tijuana | 4:0 | ||||
| 11. Round | 17/03/2019 | Club Tijuana | - | CF Monterrey | 1:0 | ||||
| 12. Round | 30/03/2019 | Gallos Blancos | - | Club Tijuana | 1:0 | ||||
| 13. Round | 07/04/2019 | Club Tijuana | - | CF América | 3:2 | ||||
| 14. Round | 14/04/2019 | Pumas UNAM | - | Club Tijuana | 1:0 | ||||
| 15. Round | 20/04/2019 | Club Tijuana | - | Lobos BUAP | 1:2 | ||||
| 17. Round | 05/05/2019 | Club Tijuana | - | Puebla FC | 4:0 |  |
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