| 1. Round | 08/09/1990 | US Lecce | - | SSC Napoli | 0:0 | ||||
| 3. Round | 22/09/1990 | Parma AC | - | SSC Napoli | 1:0 | ||||
| 4. Round | 29/09/1990 | SSC Napoli | - | Pisa SC | 2:1 |  |
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| 6. Round | 21/10/1990 | SSC Napoli | - | AC Milan | 1:1 | |
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| 7. Round | 28/10/1990 | SSC Napoli | - | ACF Fiorentina | 1:0 |  |
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| 9. Round | 17/11/1990 | SSC Napoli | - | Sampdoria | 1:4 | ||||
| 10. Round | 24/11/1990 | Inter | - | SSC Napoli | 2:1 | ||||
| 11. Round | 01/12/1990 | SSC Napoli | - | Torino FC | 2:1 | |
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| 13. Round | 15/12/1990 | SSC Napoli | - | Lazio Roma | 2:1 | ||||
| 15. Round | 05/01/1991 | Juventus | - | SSC Napoli | 1:0 | ||||
| 17. Round | 19/01/1991 | Bologna FC | - | SSC Napoli | 1:0 | ||||
| 18. Round | 26/01/1991 | SSC Napoli | - | US Lecce | 2:2 | ||||
| 20. Round | 09/02/1991 | SSC Napoli | - | Parma AC | 4:2 | |
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| 21. Round | 16/02/1991 | Pisa SC | - | SSC Napoli | 1:1 | ||||
| 22. Round | 23/02/1991 | SSC Napoli | - | Genoa CFC | 1:0 | ||||
| 23. Round | 02/03/1991 | AC Milan | - | SSC Napoli | 4:1 | ||||
| 25. Round | 16/03/1991 | SSC Napoli | - | AS Bari | 1:0 | ||||
| 26. Round | 23/03/1991 | Sampdoria | - | SSC Napoli | 4:1 | |
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Argentina
