| 1. Round | 19/01/2022 | Club León [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 3. Round | 27/01/2022 | CF América [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U20] | - | Pumas UNAM [U20] | 0:0 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U20] | - | Atlas Guadalajara [U20] | 2:1 | ||||
| 8. Round | 02/03/2022 | Atlas Guadalajara [U20] | - | CF Pachuca [U20] | 0:3 | ||||
| 9. Round | 05/03/2022 | Gallos Blancos [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 10. Round | 11/03/2022 | FC Juárez [U20] | - | Atlas Guadalajara [U20] | 0:0 | ||||
| 14. Round | 14/04/2022 | Atlas Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 15. Round | 20/04/2022 | CF Monterrey [U20] | - | Atlas Guadalajara [U20] | 0:0 |  |
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| 16. Round | 24/04/2022 | Deportivo Toluca [U20] | - | Atlas Guadalajara [U20] | 2:1 | ||||
| 17. Round | 30/04/2022 | Atlas Guadalajara [U20] | - | UANL Tigres [U20] | 0:0 |
Mexico