| 1. Round | 16/07/2021 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
| 2. Round | 23/07/2021 | San Lorenzo II | - | Central Córdoba SdE II | 1:0 | ||||
| 4. Round | 30/07/2021 | San Lorenzo II | - | Banfield II | 2:3 |  |
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| 5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 |
Argentina