| 1. Round | 06/03/1999 | Vélez Sarsfield | - | River Plate | 0:1 | ||||
| 2. Round | 13/03/1999 | River Plate | - | Argentinos Juniors | 2:0 | ||||
| 3. Round | 20/03/1999 | River Plate | - | Estudiantes | 1:0 | ||||
| 4. Round | 27/03/1999 | San Lorenzo | - | River Plate | 2:2 | ||||
| 5. Round | 30/03/1999 | River Plate | - | Talleres de Córdoba | 3:0 | ||||
| 6. Round | 02/04/1999 | Rosario Central | - | River Plate | 3:1 | ||||
| 7. Round | 10/04/1999 | River Plate | - | Independiente | 2:1 | ||||
| 8. Round | 17/04/1999 | Lanús | - | River Plate | 1:1 | ||||
| 9. Round | 24/04/1999 | River Plate | - | Unión de Santa Fe | 1:0 | ||||
| 10. Round | 27/04/1999 | Ferro Carril Oeste | - | River Plate | 2:2 | ||||
| 11. Round | 01/05/1999 | River Plate | - | Gimnasia de Jujuy | 8:0 | ||||
| 12. Round | 08/05/1999 | Boca Juniors | - | River Plate | 2:1 | ||||
| 13. Round | 15/05/1999 | River Plate | - | Gimnasia de La Plata | 3:1 | ||||
| 14. Round | 21/05/1999 | Huracán | - | River Plate | 0:1 | ||||
| 15. Round | 29/05/1999 | River Plate | - | Belgrano de Córdoba | 1:0 | ||||
| 16. Round | 01/06/1999 | Newell's Old Boys | - | River Plate | 3:1 | ||||
| 17. Round | 05/06/1999 | River Plate | - | Racing Club | 2:3 |  |
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| 18. Round | 12/06/1999 | Platense | - | River Plate | 0:3 |
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