| 1. Round | 08/08/2010 | Gimnasia de La Plata | - | San Lorenzo | 0:0 | ||||
| 2. Round | 15/08/2010 | San Lorenzo | - | Godoy Cruz | 2:2 | ||||
| 3. Round | 22/08/2010 | Racing Club | - | San Lorenzo | 1:2 |  |
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| 4. Round | 29/08/2010 | San Lorenzo | - | All Boys | 3:1 | ||||
| 7. Round | 18/09/2010 | San Lorenzo | - | Olimpo de Bahía Blanca | 3:1 | ||||
| 8. Round | 26/09/2010 | Colón de Santa Fe | - | San Lorenzo | 2:0 | |
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| 9. Round | 03/10/2010 | San Lorenzo | - | Estudiantes | 0:1 | ||||
| 10. Round | 09/10/2010 | Lanús | - | San Lorenzo | 2:0 | ||||
| 13. Round | 07/11/2010 | San Lorenzo | - | Independiente | 1:1 | |
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| 16. Round | 27/11/2010 | Arsenal de Sarandí | - | San Lorenzo | 2:1 | ||||
| 19. Round | 12/12/2010 | San Lorenzo | - | Banfield | 2:1 |
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