2. Round | 16/01/2022 | Deportivo Toluca | - | Santos Laguna | 3:1 | ||||
3. Round | 22/01/2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 | ||||
5. Round | 12/02/2022 | Atlético San Luis | - | Deportivo Toluca | 0:1 | ||||
7. Round | 25/02/2022 | Gallos Blancos | - | Deportivo Toluca | 1:1 | ||||
8. Round | 02/03/2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | ||||
9. Round | 05/03/2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | ||||
10. Round | 13/03/2022 | Deportivo Toluca | - | CF Pachuca | 0:3 | ||||
11. Round | 20/03/2022 | CF América | - | Deportivo Toluca | 3:0 | ||||
16. Round | 24/04/2022 | Deportivo Toluca | - | Atlas Guadalajara | 2:4 |