| 2. Round | 15/08/2010 | San Lorenzo | - | Godoy Cruz | 2:2 |  |
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| 3. Round | 22/08/2010 | Racing Club | - | San Lorenzo | 1:2 | ||||
| 4. Round | 29/08/2010 | San Lorenzo | - | All Boys | 3:1 | ||||
| 5. Round | 04/09/2010 | Boca Juniors | - | San Lorenzo | 1:2 |  |
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| 6. Round | 11/09/2010 | San Lorenzo | - | Vélez Sarsfield | 0:0 | ||||
| 7. Round | 18/09/2010 | San Lorenzo | - | Olimpo de Bahía Blanca | 3:1 | |
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| 8. Round | 26/09/2010 | Colón de Santa Fe | - | San Lorenzo | 2:0 | ||||
| 9. Round | 03/10/2010 | San Lorenzo | - | Estudiantes | 0:1 | ||||
| 11. Round | 15/10/2010 | San Lorenzo | - | Tigre | 2:0 | ||||
| 12. Round | 24/10/2010 | Huracán | - | San Lorenzo | 3:0 | |
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| 13. Round | 07/11/2010 | San Lorenzo | - | Independiente | 1:1 | ||||
| 14. Round | 14/11/2010 | Argentinos Juniors | - | San Lorenzo | 1:0 | ||||
| 17. Round | 05/12/2010 | San Lorenzo | - | Newell's Old Boys | 0:0 |
Argentina