| 1. Round | 22/07/2019 | Santos Laguna | - | Deportivo Guadalajara | 3:0 | ||||
| 2. Round | 29/07/2019 | Santos Laguna | - | FC Juárez | 3:0 | ||||
| 3. Round | 03/08/2019 | Atlas Guadalajara | - | Santos Laguna | 1:2 | ||||
| 4. Round | 12/08/2019 | Santos Laguna | - | Puebla FC | 4:1 |  |
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| 5. Round | 18/08/2019 | Club Necaxa | - | Santos Laguna | 3:0 | ||||
| 6. Round | 24/08/2019 | Santos Laguna | - | CF Monterrey | 2:1 | ||||
| 7. Round | 29/08/2019 | Club León | - | Santos Laguna | 2:2 | ||||
| 9. Round | 16/09/2019 | Santos Laguna | - | CF Pachuca | 2:2 | ||||
| 10. Round | 21/09/2019 | Atlético San Luis | - | Santos Laguna | 2:3 | ||||
| 11. Round | 26/09/2019 | Santos Laguna | - | CD Veracruz | 5:0 | |
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| 12. Round | 29/09/2019 | Pumas UNAM | - | Santos Laguna | 2:0 |  |
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| 13. Round | 06/10/2019 | UANL Tigres | - | Santos Laguna | 4:0 | ||||
| 14. Round | 19/10/2019 | Santos Laguna | - | Club Tijuana | 4:1 | |
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| 15. Round | 26/10/2019 | Monarcas Morelia | - | Santos Laguna | 2:2 | |
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| 16. Round | 30/10/2019 | Santos Laguna | - | Gallos Blancos | 1:0 | ||||
| 17. Round | 03/11/2019 | CF América | - | Santos Laguna | 1:2 | |
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| 18. Round | 11/11/2019 | Santos Laguna | - | Cruz Azul | 3:1 | ||||
| 19. Round | 24/11/2019 | Deportivo Toluca | - | Santos Laguna | 2:2 | |
Chile