| 1. Round | 11/01/2020 | Club Tijuana | - | Santos Laguna | 2:1 |  |
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| 2. Round | 20/01/2020 | Santos Laguna | - | Club León | 3:2 |  |
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| 3. Round | 25/01/2020 | Cruz Azul | - | Santos Laguna | 3:0 | ||||
| 4. Round | 02/02/2020 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 5. Round | 08/02/2020 | Puebla FC | - | Santos Laguna | 2:2 | ||||
| 6. Round | 17/02/2020 | Santos Laguna | - | UANL Tigres | 2:1 | ||||
| 7. Round | 24/02/2020 | FC Juárez | - | Santos Laguna | 1:2 | ||||
| 8. Round | 02/03/2020 | Santos Laguna | - | Atlas Guadalajara | 1:0 | ||||
| 9. Round | 08/03/2020 | CF Pachuca | - | Santos Laguna | 1:0 | ||||
| 10. Round | 16/03/2020 | Santos Laguna | - | Club Necaxa | 2:1 |
Chile