| 3. Round | 06/08/2018 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 4. Round | 13/08/2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 | ||||
| 5. Round | 20/08/2018 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 7. Round | 27/08/2018 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
| 8. Round | 02/09/2018 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 9. Round | 16/09/2018 | Santos Laguna | - | Club León | 3:0 | ||||
| 10. Round | 24/09/2018 | Santos Laguna | - | CD Veracruz | 1:1 | ||||
| 12. Round | 06/10/2018 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 13. Round | 21/10/2018 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 14. Round | 27/10/2018 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos | - | Santos Laguna | 2:1 | ||||
| 16. Round | 12/11/2018 | Santos Laguna | - | CF América | 1:1 | ||||
| 17. Round | 25/11/2018 | Pumas UNAM | - | Santos Laguna | 1:1 |
Ecuador
Spain