| 1. Round | 06/01/2019 | Lobos BUAP | - | Santos Laguna | 2:0 | ||||
| 2. Round | 14/01/2019 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 3. Round | 19/01/2019 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 5. Round | 03/02/2019 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 6. Round | 11/02/2019 | Santos Laguna | - | Club Tijuana | 1:1 | ||||
| 7. Round | 16/02/2019 | Cruz Azul | - | Santos Laguna | 1:2 |  |
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| 8. Round | 25/02/2019 | Santos Laguna | - | Deportivo Toluca | 4:0 | |
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| 13. Round | 08/04/2019 | Santos Laguna | - | CF Pachuca | 0:0 |  |
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| 17. Round | 06/05/2019 | Santos Laguna | - | Pumas UNAM | 5:2 |
Ecuador
Spain