| 1. Round | 19/07/2021 | Central Córdoba SdE II | - | Banfield II | 1:2 | ||||
| 2. Round | 23/07/2021 | San Lorenzo II | - | Central Córdoba SdE II | 1:0 | ||||
| 3. Round | 27/07/2021 | Central Córdoba SdE II | - | Talleres de Córdoba II | 1:2 | ||||
| 9. Round | 30/08/2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 11. Round | 10/09/2021 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 | ||||
| 12. Round | 17/09/2021 | Colón de Santa Fe II | - | Central Córdoba SdE II | 0:1 | ||||
| 13. Round | 24/09/2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 17. Round | 19/10/2021 | Central Córdoba SdE II | - | Vélez Sarsfield II | 2:0 | ||||
| 19. Round | 01/11/2021 | Central Córdoba SdE II | - | Aldosivi II | 1:1 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 29/11/2021 | Central Córdoba SdE II | - | Arsenal de Sarandí II | 1:2 | ||||
| 24. Round | 03/12/2021 | Central Córdoba SdE II | - | Unión de Santa Fe II | 0:3 | ||||
| 25. Round | 11/12/2021 | Boca Juniors II | - | Central Córdoba SdE II | 7:0 |
Argentina