| 1. Round | 05/06/2022 | Independiente II | - | San Lorenzo II | 0:1 | ||||
| 2. Round | 09/06/2022 | San Lorenzo II | - | Newell's Old Boys II | 2:3 |  |
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| 3. Round | 14/06/2022 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
| 4. Round | 20/06/2022 | San Lorenzo II | - | Central Córdoba SdE II | 0:0 | ||||
| 5. Round | 25/06/2022 | Tigre II | - | San Lorenzo II | 3:2 | ||||
| 16. Round | 28/08/2022 | Rosario Central II | - | San Lorenzo II | 0:1 | ||||
| 18. Round | 07/09/2022 | Atlético Tucumán II | - | San Lorenzo II | 1:2 | |
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| 20. Round | 19/09/2022 | River Plate II | - | San Lorenzo II | 1:0 | ||||
| 21. Round | 25/09/2022 | San Lorenzo II | - | Lanús II | 1:2 | ||||
| 22. Round | 28/09/2022 | Huracán II | - | San Lorenzo II | 3:1 | |
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| 23. Round | 04/10/2022 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 24. Round | 10/10/2022 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 25. Round | 14/10/2022 | San Lorenzo II | - | Gimnasia de La Plata II | 3:1 | ||||
| 26. Round | 18/10/2022 | San Lorenzo II | - | Sarmiento de Junín II | 0:0 | ||||
| 27. Round | 23/10/2022 | Aldosivi II | - | San Lorenzo II | 2:3 | |
Argentina