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| 07/09/2022 | 14:00 | Vélez Sarsfield II | - | Arsenal de Sarandí II | 1:0 (1:0) | |
| 15:00 | Aldosivi II | - | Independiente II | 0:1 (0:1) | ||
| 15:00 | Gimnasia de La Plata II | - | Newell's Old Boys II | 2:2 (1:1) | ||
| 15:00 | Godoy Cruz II | - | Central Córdoba SdE II | 5:1 (3:1) | ||
| 15:00 | Atlético Tucumán II | - | San Lorenzo II | 1:2 (1:0) | ||
| 08/09/2022 | 14:00 | Lanús II | - | Barracas Central II | 1:0 (0:0) | |
| 15:00 | Colón de Santa Fe II | - | Banfield II | 1:1 (0:0) | ||
| 15:00 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:1 (1:0) | ||
| 15:00 | Platense II | - | Patronato de Paraná II | 2:2 (2:0) | ||
| 09/09/2022 | 14:00 | Huracán II | - | Tigre II | 1:2 (0:1) | |
| 14:00 | Racing Club II | - | Estudiantes II | 1:2 (1:1) | ||
| 15:00 | Sarmiento de Junín II | - | Unión de Santa Fe II | 1:0 (0:0) | ||
| 15:00 | Rosario Central II | - | Argentinos Juniors II | 0:0 (0:0) | ||
| 10/09/2022 | 15:00 | River Plate II | - | Boca Juniors II | 1:2 (0:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 18 | 13 | 1 | 4 | 35:12 | 23 | 40 |
| 2 |
|
Vélez Sarsfield II | 18 | 11 | 2 | 5 | 32:11 | 21 | 35 |
| 3 |
|
Argentinos Juniors II | 18 | 9 | 6 | 3 | 27:15 | 12 | 33 |
| 4 |
|
Newell's Old Boys II | 18 | 8 | 7 | 3 | 24:17 | 7 | 31 |
| 5 |
|
Huracán II | 18 | 9 | 3 | 6 | 35:28 | 7 | 30 |
| 6 |
|
Gimnasia de La Plata II | 18 | 8 | 5 | 5 | 30:23 | 7 | 29 |
| 7 |
|
Tigre II | 18 | 8 | 5 | 5 | 21:20 | 1 | 29 |
| 8 |
|
Defensa y Justicia II | 18 | 9 | 2 | 7 | 21:22 | -1 | 29 |
| 9 |
|
Independiente II | 18 | 8 | 4 | 6 | 28:24 | 4 | 28 |
| 10 |
|
River Plate II | 18 | 9 | 1 | 8 | 21:17 | 4 | 28 |
| 11 |
|
San Lorenzo II | 18 | 8 | 3 | 7 | 23:21 | 2 | 27 |
| 12 |
|
Lanús II | 18 | 8 | 3 | 7 | 29:30 | -1 | 27 |
| 13 |
|
Rosario Central II | 18 | 7 | 5 | 6 | 31:27 | 4 | 26 |
| 14 |
|
Unión de Santa Fe II | 18 | 6 | 7 | 5 | 17:15 | 2 | 25 |
| 15 |
|
Colón de Santa Fe II | 18 | 6 | 7 | 5 | 23:25 | -2 | 25 |
| 16 |
|
Banfield II | 18 | 6 | 6 | 6 | 16:17 | -1 | 24 |
| 17 |
|
Talleres de Córdoba II | 18 | 6 | 4 | 8 | 22:25 | -3 | 22 |
| 18 |
|
Central Córdoba SdE II | 18 | 6 | 4 | 8 | 18:28 | -10 | 22 |
| 19 |
|
Atlético Tucumán II | 18 | 6 | 3 | 9 | 24:26 | -2 | 21 |
|
Godoy Cruz II | 18 | 5 | 6 | 7 | 24:26 | -2 | 21 | |
| 21 |
|
Estudiantes II | 18 | 4 | 8 | 6 | 13:18 | -5 | 20 |
| 22 |
|
Arsenal de Sarandí II | 18 | 4 | 7 | 7 | 17:20 | -3 | 19 |
| 23 |
|
Racing Club II | 18 | 4 | 6 | 8 | 24:23 | 1 | 18 |
| 24 |
|
Platense II | 18 | 3 | 9 | 6 | 13:18 | -5 | 18 |
| 25 |
|
Sarmiento de Junín II | 18 | 5 | 3 | 10 | 14:27 | -13 | 18 |
| 26 |
|
Aldosivi II | 18 | 5 | 2 | 11 | 25:38 | -13 | 17 |
| 27 |
|
Patronato de Paraná II | 18 | 4 | 4 | 10 | 15:29 | -14 | 16 |
| 28 |
|
Barracas Central II | 18 | 5 | 1 | 12 | 11:31 | -20 | 16 |
