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| 03/10/2022 | 14:00 | Unión de Santa Fe II | - | Rosario Central II | 1:0 (0:0) | |
| 14:00 | Racing Club II | - | Defensa y Justicia II | 1:1 (1:1) | ||
| 14:00 | Arsenal de Sarandí II | - | Newell's Old Boys II | 1:2 (0:0) | ||
| 15:00 | Platense II | - | Atlético Tucumán II | 3:0 (0:0) | ||
| 15:00 | Barracas Central II | - | Aldosivi II | 2:2 (1:0) | ||
| 04/10/2022 | 14:00 | Estudiantes II | - | River Plate II | 2:0 (1:0) | |
| 15:00 | Argentinos Juniors II | - | Lanús II | 1:3 (0:3) | ||
| 15:00 | Talleres de Córdoba II | - | Huracán II | 1:0 (0:0) | ||
| 15:00 | San Lorenzo II | - | Godoy Cruz II | 0:1 (0:0) | ||
| 20:30 | Patronato de Paraná II | - | Colón de Santa Fe II | 1:2 (1:0) | ||
| 05/10/2022 | 14:00 | Boca Juniors II | - | Gimnasia de La Plata II | 2:1 (1:0) | |
| 15:00 | Banfield II | - | Vélez Sarsfield II | 1:3 (1:1) | ||
| 15:00 | Tigre II | - | Sarmiento de Junín II | 1:1 (0:1) | ||
| 15:00 | Central Córdoba SdE II | - | Independiente II | 0:1 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 23 | 14 | 3 | 6 | 39:19 | 20 | 45 |
| 2 |
|
Vélez Sarsfield II | 23 | 14 | 2 | 7 | 40:17 | 23 | 44 |
| 3 |
|
Newell's Old Boys II | 23 | 11 | 7 | 5 | 32:23 | 9 | 40 |
| 4 |
|
Tigre II | 23 | 11 | 7 | 5 | 29:23 | 6 | 40 |
| 5 |
|
Huracán II | 23 | 12 | 3 | 8 | 46:35 | 11 | 39 |
| 6 |
|
Independiente II | 23 | 11 | 5 | 7 | 37:27 | 10 | 38 |
| 7 |
|
Lanús II | 23 | 11 | 4 | 8 | 38:37 | 1 | 37 |
| 8 |
|
River Plate II | 23 | 12 | 1 | 10 | 24:24 | 0 | 37 |
| 9 |
|
Gimnasia de La Plata II | 23 | 10 | 6 | 7 | 42:29 | 13 | 36 |
| 10 |
|
Argentinos Juniors II | 23 | 9 | 9 | 5 | 31:22 | 9 | 36 |
| 11 |
|
Defensa y Justicia II | 23 | 10 | 5 | 8 | 26:24 | 2 | 35 |
| 12 |
|
Talleres de Córdoba II | 23 | 10 | 4 | 9 | 35:30 | 5 | 34 |
| 13 |
|
Colón de Santa Fe II | 23 | 8 | 8 | 7 | 32:32 | 0 | 32 |
| 14 |
|
Unión de Santa Fe II | 23 | 8 | 8 | 7 | 21:21 | 0 | 32 |
| 15 |
|
Rosario Central II | 23 | 8 | 7 | 8 | 35:32 | 3 | 31 |
| 16 |
|
Godoy Cruz II | 23 | 8 | 7 | 8 | 30:28 | 2 | 31 |
| 17 |
|
San Lorenzo II | 23 | 9 | 3 | 11 | 27:29 | -2 | 30 |
| 18 |
|
Estudiantes II | 23 | 7 | 9 | 7 | 21:23 | -2 | 30 |
| 19 |
|
Banfield II | 23 | 8 | 6 | 9 | 23:26 | -3 | 30 |
| 20 |
|
Platense II | 23 | 6 | 11 | 6 | 23:22 | 1 | 29 |
| 21 |
|
Arsenal de Sarandí II | 23 | 6 | 9 | 8 | 23:24 | -1 | 27 |
| 22 |
|
Central Córdoba SdE II | 23 | 7 | 4 | 12 | 21:35 | -14 | 25 |
| 23 |
|
Sarmiento de Junín II | 23 | 7 | 4 | 12 | 19:35 | -16 | 25 |
| 24 |
|
Racing Club II | 23 | 5 | 8 | 10 | 29:29 | 0 | 23 |
| 25 |
|
Atlético Tucumán II | 23 | 6 | 5 | 12 | 28:38 | -10 | 23 |
| 26 |
|
Patronato de Paraná II | 23 | 5 | 5 | 13 | 18:37 | -19 | 20 |
| 27 |
|
Barracas Central II | 23 | 6 | 2 | 15 | 17:45 | -28 | 20 |
| 28 |
|
Aldosivi II | 23 | 5 | 4 | 14 | 28:48 | -20 | 19 |
