| 1. Round | 08/01/2023 | Pumas UNAM | - | FC Juárez | 2:1 |  |
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| 2. Round | 15/01/2023 | Santos Laguna | - | Pumas UNAM | 3:0 | ||||
| 3. Round | 22/01/2023 | Pumas UNAM | - | Club León | 4:1 | ||||
| 7. Round | 16/02/2023 | Club Necaxa | - | Pumas UNAM | 3:1 | ||||
| 8. Round | 19/02/2023 | Pumas UNAM | - | Deportivo Guadalajara | 1:2 | ||||
| 9. Round | 25/02/2023 | Mazatlán FC | - | Pumas UNAM | 1:2 | |
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| 10. Round | 05/03/2023 | Pumas UNAM | - | Puebla FC | 2:4 | |
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| 11. Round | 12/03/2023 | Cruz Azul | - | Pumas UNAM | 1:0 | ||||
| 12. Round | 19/03/2023 | Pumas UNAM | - | CF Pachuca | 0:2 | ||||
| 13. Round | 03/04/2023 | Gallos Blancos | - | Pumas UNAM | 1:0 | ||||
| 14. Round | 09/04/2023 | Pumas UNAM | - | Atlético San Luis | 3:1 | ||||
| 15. Round | 16/04/2023 | Pumas UNAM | - | Deportivo Toluca | 3:1 | |
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| 16. Round | 23/04/2023 | CF América | - | Pumas UNAM | 1:1 | ||||
| 17. Round | 30/04/2023 | CF Monterrey | - | Pumas UNAM | 4:1 |
Argentina