| 9. Round | 26/02/2018 | Santos Laguna | - | Cruz Azul | 2:0 | ||||
| 11. Round | 12/03/2018 | Santos Laguna | - | CF Monterrey | 3:2 | ||||
| 12. Round | 17/03/2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 13. Round | 31/03/2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
| 14. Round | 09/04/2018 | Santos Laguna | - | Gallos Blancos | 3:0 | ||||
| 15. Round | 15/04/2018 | CF Pachuca | - | Santos Laguna | 3:1 | ||||
| 16. Round | 23/04/2018 | Santos Laguna | - | Pumas UNAM | 1:2 |  |
Colombia