| 18. Round | 02/09/2021 | San Marcos | - | Deportes Iquique | 4:2 | ||||
| 19. Round | 05/09/2021 | Deportes Iquique | - | Barnechea | 4:2 |  |
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| 20. Round | 16/09/2021 | San Luis | - | Deportes Iquique | 1:1 | ||||
| 21. Round | 23/09/2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 |  |
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| 22. Round | 27/09/2021 | CD Magallanes | - | Deportes Iquique | 2:2 | |
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| 23. Round | 03/10/2021 | Deportes Iquique | - | Santa Cruz | 6:1 | |
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| 24. Round | 08/10/2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 25. Round | 13/10/2021 | Deportes Iquique | - | Cobreloa | 1:0 |
Venezuela