| 5. Round | 23/07/2022 | Club León [] | - | Club Tijuana [] | 0:1 | ||||
| 7. Round | 05/08/2022 | Club León [] | - | Atlético San Luis [] | 2:0 | ||||
| 8. Round | 13/08/2022 | Mazatlán FC [] | - | Club León [] | 3:0 | ||||
| 10. Round | 27/08/2022 | Club León [] | - | Atlas Guadalajara [] | 5:0 | ||||
| 11. Round | 03/09/2022 | Santos Laguna [] | - | Club León [] | 2:0 | ||||
| 12. Round | 10/09/2022 | Club León [] | - | Mazatlán FC [] | 1:0 | ||||
| 13. Round | 18/09/2022 | Atlético San Luis [] | - | Club León [] | 0:4 |  |
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| 9. Round | 21/09/2022 | Club León [] | - | Santos Laguna [] | 4:1 | |
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| 14. Round | 24/09/2022 | Club León [] | - | CF Monterrey [] | 2:2 | ||||
| 16. Round | 08/10/2022 | Club León [] | - | Deportivo Guadalajara [] | 1:1 | |
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| 15. Round | 12/10/2022 | Club Tijuana [] | - | Club León [] | 5:1 | ||||
| 18. Round | 22/10/2022 | UANL Tigres [] | - | Club León [] | 3:1 | |
Mexico