| 2. Round | 22/05/2021 | Cerro Largo | - | Cerrito | 3:1 | ||||
| 3. Round | 29/05/2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 1. Round | 03/06/2021 | Nacional | - | Cerro Largo | 1:2 |  |
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| 4. Round | 06/06/2021 | Cerro Largo | - | River Plate | 2:4 | ||||
| 5. Round | 13/06/2021 | Deportivo Maldonado | - | Cerro Largo | 2:1 | ||||
| 6. Round | 19/06/2021 | Progreso | - | Cerro Largo | 0:0 |  |
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| 7. Round | 22/06/2021 | Cerro Largo | - | Sud América | 2:1 | ||||
| 8. Round | 28/06/2021 | Plaza Colonia | - | Cerro Largo | 1:1 | ||||
| 9. Round | 03/07/2021 | Cerro Largo | - | Fénix | 1:2 | ||||
| 10. Round | 11/07/2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Round | 17/07/2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | ||||
| 12. Round | 30/07/2021 | Rentistas | - | Cerro Largo | 1:3 | |
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| 13. Round | 06/08/2021 | Cerro Largo | - | Peñarol | 0:1 | ||||
| 14. Round | 15/08/2021 | Montevideo City Torque | - | Cerro Largo | 3:0 | ||||
| 15. Round | 22/08/2021 | Cerro Largo | - | Villa Española | 3:1 |
Uruguay