| 2. Round | 14/01/2022 | Club Necaxa [U20] | - | CF Monterrey [U20] | 1:1 | ||||
| 3. Round | 23/01/2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 0:3 |  |
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| 6. Round | 18/02/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:1 | ||||
| 7. Round | 25/02/2022 | Club Necaxa [U20] | - | Club León [U20] | 0:3 | ||||
| 8. Round | 01/03/2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 10. Round | 11/03/2022 | Club Necaxa [U20] | - | Gallos Blancos [U20] | 2:1 | |
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| 11. Round | 19/03/2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 12. Round | 02/04/2022 | Club Necaxa [U20] | - | CF América [U20] | 1:2 | ||||
| 13. Round | 07/04/2022 | Atlas Guadalajara [U20] | - | Club Necaxa [U20] | 1:1 | ||||
| 14. Round | 15/04/2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 | |
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| 15. Round | 19/04/2022 | Club Necaxa [U20] | - | UANL Tigres [U20] | 0:2 | ||||
| 16. Round | 22/04/2022 | Puebla FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 17. Round | 29/04/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 0:3 |
Mexico