| 2. Round | 10/06/2021 | Rampla Juniors | - | Racing | 2:2 | ||||
| 3. Round | 16/06/2021 | Villa Teresa | - | Rampla Juniors | 0:1 | ||||
| 10. Round | 05/08/2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Round | 12/08/2021 | Rampla Juniors | - | Central Español | 2:1 | ||||
| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | ||||
| 13. Round | 22/09/2021 | Racing | - | Rampla Juniors | 2:0 | ||||
| 14. Round | 29/09/2021 | Rampla Juniors | - | Villa Teresa | 0:0 | ||||
| 20. Round | 10/11/2021 | CA Cerro | - | Rampla Juniors | 1:2 |
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