| 1. Round | 16/07/2021 | Vélez Sarsfield II | - | Racing Club II | 1:1 | ||||
| 5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
| 6. Round | 13/08/2021 | River Plate II | - | Vélez Sarsfield II | 1:2 | ||||
| 8. Round | 25/08/2021 | Huracán II | - | Vélez Sarsfield II | 2:2 | ||||
| 10. Round | 03/09/2021 | Vélez Sarsfield II | - | Unión de Santa Fe II | 2:2 | ||||
| 11. Round | 10/09/2021 | Gimnasia de La Plata II | - | Vélez Sarsfield II | 2:3 | ||||
| 13. Round | 24/09/2021 | Sarmiento de Junín II | - | Vélez Sarsfield II | 0:4 | ||||
| 15. Round | 08/10/2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 16. Round | 13/10/2021 | Vélez Sarsfield II | - | Arsenal de Sarandí II | 1:1 | ||||
| 17. Round | 19/10/2021 | Central Córdoba SdE II | - | Vélez Sarsfield II | 2:0 | ||||
| 9. Round | 11/11/2021 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 | ||||
| 24. Round | 06/12/2021 | Vélez Sarsfield II | - | Patronato de Paraná II | 1:0 |
Argentina