| 1. Round | 14/03/2021 | Brown de Adrogué | - | Guillermo Brown | 1:0 | ||||
| 2. Round | 21/03/2021 | Guillermo Brown | - | San Martín de San Juan | 0:0 | ||||
| 19. Round | 31/07/2021 | San Martín de San Juan | - | Guillermo Brown | 0:0 | ||||
| 21. Round | 15/08/2021 | San Telmo | - | Guillermo Brown | 1:2 |  |
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| 22. Round | 21/08/2021 | Guillermo Brown | - | Defensores de Belgrano | 1:1 | ||||
| 23. Round | 29/08/2021 | Ramón Santamarina | - | Guillermo Brown | 1:1 | ||||
| 33. Round | 06/11/2021 | Atlético Rafaela | - | Guillermo Brown | 0:1 | ||||
| 34. Round | 12/11/2021 | Guillermo Brown | - | All Boys | 1:0 | |
Argentina