5. Round | 16/09/2021 | İstanbulspor AŞ | - | MKE Ankaragücü | 0:1 | ||||
6. Round | 20/09/2021 | Boluspor | - | İstanbulspor AŞ | 1:1 | ||||
7. Round | 26/09/2021 | İstanbulspor AŞ | - | Balıkesirspor | 1:0 | ||||
8. Round | 02/10/2021 | Kocaelispor | - | İstanbulspor AŞ | 2:1 | ||||
11. Round | 31/10/2021 | Gençlerbirliği | - | İstanbulspor AŞ | 0:2 |