| 1. Round | 16/07/2021 | Unión de Santa Fe II | - | Boca Juniors II | 1:0 | ||||
| 4. Round | 02/08/2021 | Talleres de Córdoba II | - | Boca Juniors II | 1:1 | ||||
| 5. Round | 06/08/2021 | Boca Juniors II | - | Argentinos Juniors II | 0:1 | ||||
| 6. Round | 13/08/2021 | Estudiantes II | - | Boca Juniors II | 2:1 |  |
|||
| 7. Round | 19/08/2021 | Boca Juniors II | - | Patronato de Paraná II | 4:0 | |
|||
| 8. Round | 24/08/2021 | Platense II | - | Boca Juniors II | 2:2 | ||||
| 9. Round | 27/08/2021 | Boca Juniors II | - | Racing Club II | 4:0 | |
|||
| 20. Round | 04/11/2021 | Aldosivi II | - | Boca Juniors II | 1:1 | ||||
| 3. Round | 11/11/2021 | Boca Juniors II | - | San Lorenzo II | 4:1 |
Argentina