| 7. Round | 24/02/2022 | Gallos Blancos [U20] | - | Deportivo Toluca [U20] | 0:1 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 10. Round | 13/03/2022 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 11. Round | 20/03/2022 | CF América [U20] | - | Deportivo Toluca [U20] | 2:0 |
Mexico