| 4. Round | 30/07/2021 | Defensa y Justicia II | - | Gimnasia de La Plata II | 0:5 | ||||
| 5. Round | 06/08/2021 | Aldosivi II | - | Defensa y Justicia II | 1:2 | ||||
| 6. Round | 13/08/2021 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:0 |  |
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| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 8. Round | 24/08/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 | ||||
| 11. Round | 09/09/2021 | Boca Juniors II | - | Defensa y Justicia II | 3:2 | ||||
| 12. Round | 20/09/2021 | Defensa y Justicia II | - | Banfield II | 0:2 |
Argentina