| 1. Round | 16/07/2021 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
| 2. Round | 23/07/2021 | San Lorenzo II | - | Central Córdoba SdE II | 1:0 | ||||
| 4. Round | 30/07/2021 | San Lorenzo II | - | Banfield II | 2:3 | ||||
| 5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
| 8. Round | 23/08/2021 | Estudiantes II | - | San Lorenzo II | 2:2 | ||||
| 9. Round | 30/08/2021 | San Lorenzo II | - | Patronato de Paraná II | 2:2 | ||||
| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 21. Round | 18/11/2021 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 | ||||
| 22. Round | 23/11/2021 | Aldosivi II | - | San Lorenzo II | 1:0 | ||||
| 23. Round | 27/11/2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 | ||||
| 24. Round | 06/12/2021 | Independiente II | - | San Lorenzo II | 1:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina