1. Round | 16/07/2021 | Independiente II | - | Argentinos Juniors II | 3:0 | ||||
2. Round | 23/07/2021 | Estudiantes II | - | Independiente II | 2:2 | ||||
6. Round | 13/08/2021 | Rosario Central II | - | Independiente II | 3:1 | ||||
7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
19. Round | 29/10/2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
21. Round | 19/11/2021 | Central Córdoba SdE II | - | Independiente II | 2:3 | ||||
22. Round | 24/11/2021 | Independiente II | - | Boca Juniors II | 0:0 |