| 1. Round | 13/03/2021 | San Telmo | - | Barracas Central | 1:1 | ||||
| 2. Round | 22/03/2021 | Independiente Rivadavia | - | San Telmo | 4:3 |  |
|||
| 3. Round | 28/03/2021 | San Telmo | - | Atlético Rafaela | 0:0 | ||||
| 4. Round | 04/04/2021 | Guillermo Brown | - | San Telmo | 1:2 | ||||
| 5. Round | 11/04/2021 | San Telmo | - | Brown de Adrogué | 2:1 |  |
|||
| 7. Round | 25/04/2021 | San Telmo | - | Villa Dálmine | 1:0 | ||||
| 8. Round | 02/05/2021 | San Telmo | - | All Boys | 1:1 | ||||
| 9. Round | 10/05/2021 | Defensores de Belgrano | - | San Telmo | 0:0 | ||||
| 10. Round | 16/05/2021 | San Telmo | - | Ramón Santamarina | 2:2 |
Argentina