| 2. Round | 21/02/2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 3. Round | 01/03/2022 | Santiago Wanderers | - | Santiago Morning | 2:2 |  |
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| 4. Round | 09/03/2022 | San Luis | - | Santiago Wanderers | 1:1 |  |
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| 5. Round | 16/03/2022 | Santiago Wanderers | - | Rangers | 1:3 | |
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| 6. Round | 22/03/2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | ||||
| 7. Round | 03/04/2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | ||||
| 8. Round | 09/04/2022 | Deportes Copiapó | - | Santiago Wanderers | 1:1 | ||||
| 9. Round | 16/04/2022 | Santiago Wanderers | - | Puerto Montt | 2:0 | |
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| 13. Round | 06/05/2022 | Santiago Wanderers | - | Barnechea | 1:3 | ||||
| 14. Round | 13/05/2022 | Cobreloa | - | Santiago Wanderers | 1:1 | |
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| 17. Round | 27/05/2022 | Santa Cruz | - | Santiago Wanderers | 2:0 | ||||
| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 | ||||
| 11. Round | 09/06/2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 |
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