| Group B | 22/04/2021 | CD Guabirá | - | Independiente | 1:3 | ||||
| Group B | 28/04/2021 | Independiente | - | Montevideo City Torque | 3:1 | ||||
| Group B | 04/05/2021 | Bahia - BA | - | Independiente | 2:2 | ||||
| Group B | 12/05/2021 | Montevideo City Torque | - | Independiente | 1:1 |  |
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| Group B | 18/05/2021 | Independiente | - | Bahia - BA | 1:0 | |
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| Group B | 26/05/2021 | Independiente | - | CD Guabirá | 1:0 | ||||
| Round of 16 | 15/07/2021 | Santos FC | - | Independiente | 1:0 | ||||
| Round of 16 | 22/07/2021 | Independiente | - | Santos FC | 1:1 |
Argentina