| 1. Round | 08/01/2018 | Santos Laguna | - | Lobos BUAP | 4:2 | ||||
| 2. Round | 13/01/2018 | Lobos BUAP | - | Gallos Blancos | 0:2 | ||||
| 3. Round | 21/01/2018 | CF Pachuca | - | Lobos BUAP | 3:1 | ||||
| 5. Round | 04/02/2018 | CF América | - | Lobos BUAP | 5:1 | ||||
| 6. Round | 10/02/2018 | Lobos BUAP | - | Atlas Guadalajara | 3:1 | ||||
| 7. Round | 14/02/2018 | Lobos BUAP | - | UANL Tigres | 0:0 | ||||
| 8. Round | 17/02/2018 | Monarcas Morelia | - | Lobos BUAP | 2:1 | ||||
| 9. Round | 24/02/2018 | Lobos BUAP | - | CD Veracruz | 5:0 |  |
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| 10. Round | 03/03/2018 | Club Tijuana | - | Lobos BUAP | 3:1 | ||||
| 11. Round | 10/03/2018 | Lobos BUAP | - | Deportivo Guadalajara | 0:1 | ||||
| 12. Round | 18/03/2018 | Club León | - | Lobos BUAP | 2:2 | ||||
| 13. Round | 01/04/2018 | Lobos BUAP | - | Deportivo Toluca | 1:2 | ||||
| 15. Round | 14/04/2018 | Lobos BUAP | - | Club Necaxa | 0:1 |
Argentina