| Group B | 13/06/2022 | Defensor Sporting | - | Nacional | 0:1 | ||||
| Group B | 20/06/2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| Group B | 25/06/2022 | Defensor Sporting | - | Cerro Largo | 1:0 |  |
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| Group B | 10/07/2022 | Boston River | - | Defensor Sporting | 2:3 | ||||
| Group B | 17/07/2022 | Defensor Sporting | - | Danubio | 2:1 | ||||
| Group B | 21/07/2022 | River Plate | - | Defensor Sporting | 1:1 |
Uruguay