1. Round | 05/02/2021 | Sportivo Luqueño | - | Guaireña FC | 3:1 | ||||
3. Round | 14/02/2021 | Club Olimpia | - | Guaireña FC | 0:0 | ||||
4. Round | 21/02/2021 | Cerro Porteño | - | Guaireña FC | 2:2 | ||||
2. Round | 24/02/2021 | Guaireña FC | - | Libertad | 1:0 | ||||
5. Round | 01/03/2021 | Guaireña FC | - | Club Nacional | 1:0 | ||||
11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
12. Round | 16/04/2021 | Guaireña FC | - | Club Olimpia | 1:2 | ||||
13. Round | 25/04/2021 | Guaireña FC | - | Cerro Porteño | 0:1 | ||||
14. Round | 30/04/2021 | Club Nacional | - | Guaireña FC | 1:3 | ||||
15. Round | 10/05/2021 | Guaireña FC | - | River Plate | 0:0 | ||||
16. Round | 16/05/2021 | 12 de Octubre de Itauguá | - | Guaireña FC | 1:1 | ||||
17. Round | 22/05/2021 | Guaireña FC | - | Guaraní | 0:0 | ||||
18. Round | 28/05/2021 | Sol de América | - | Guaireña FC | 0:0 |