| 3. Round | 27/07/2021 | Unión de Santa Fe II | - | Banfield II | 0:1 | ||||
| 4. Round | 30/07/2021 | Lanús II | - | Unión de Santa Fe II | 2:1 | ||||
| 5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 7. Round | 20/08/2021 | Unión de Santa Fe II | - | Talleres de Córdoba II | 2:2 | ||||
| 10. Round | 03/09/2021 | Vélez Sarsfield II | - | Unión de Santa Fe II | 2:2 | ||||
| 11. Round | 10/09/2021 | Unión de Santa Fe II | - | Estudiantes II | 1:4 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 |
Argentina
Italy