| 1. Round | 05/08/2021 | Santos FC | - | Unión Huaral | 1:3 | ||||
| 2. Round | 10/08/2021 | Chavelines Juniors | - | Santos FC | 3:0 | ||||
| 3. Round | 13/08/2021 | Santos FC | - | Deportivo Coopsol | 1:4 |  |
|||
| 4. Round | 20/08/2021 | Juan Aurich | - | Santos FC | 2:2 | ||||
| 5. Round | 26/08/2021 | Santos FC | - | Pirata | 2:0 |  |
|||
| 6. Round | 01/09/2021 | Comerciantes Unidos | - | Santos FC | 2:1 | |
|||
| 8. Round | 12/09/2021 | Santos FC | - | Unión Comercio | 0:1 | |
Argentina
Spain