1. Round | 17/07/2021 | Cañuelas | - | Villa San Carlos | 3:0 | ||||
2. Round | 24/07/2021 | Villa San Carlos | - | Acassuso | 0:2 | ||||
13. Round | 09/10/2021 | Villa San Carlos | - | UAI Urquiza | 1:1 | ||||
14. Round | 17/10/2021 | Talleres (RdE) | - | Villa San Carlos | 2:2 | ||||
15. Round | 24/10/2021 | Villa San Carlos | - | Atlético San Miguel | 4:2 |